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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Sep 5, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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New Markers for Placental Dysfunction at Term - Potential for More.

Oliver Graupner1,2, Bettina Kuschel2, Roland Axt-Fliedner3

  • 1Klinik für Gynäkologie und Geburtsmedizin, Universitätsklinikum Aachen, RWTH Aachen, Aachen.

Geburtshilfe Und Frauenheilkunde
|July 11, 2022
PubMed
Summary

Subclinical placental dysfunction (PD) at term can impact perinatal outcomes. This review explores ultrasound markers and biomarkers to detect PD, potentially guiding early labor induction to reduce risks.

Keywords:
induction of laborplacentapregnancyultrasound

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Fetal Medicine

Background:

  • Placental reserve capacity is crucial for perinatal outcomes.
  • Current term/late-term fetal monitoring may miss subclinical placental dysfunction (PD).

Purpose of the Study:

  • To review literature on detecting placental dysfunction at term.
  • To explore complementary ultrasound markers and biomarkers for PD detection.

Main Methods:

  • Narrative literature review.
  • Analysis of fetomaternal Doppler ultrasound parameters.
  • Evaluation of fetal cardiac function.
  • Assessment of maternal serum (anti-)angiogenic factors.

Main Results:

  • Fetomaternal Doppler, fetal cardiac function, and serum biomarkers are potential PD markers.
  • These markers may identify pregnancies benefiting from early induction of labor.

Conclusions:

  • Complementary ultrasound and biomarkers show promise for detecting subclinical placental dysfunction at term.
  • Further randomized controlled trials are needed to establish optimal use for delivery timing and reduce perinatal morbidity and mortality.