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Serum ciliary neurotrophic factor levels in children with attention deficit hyperactivity disorder

Dicle Buyuktaskin1,2, Esra Guney1, Ozlem Gulbahar3

  • 1Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey.

The International Journal of Neuroscience
|July 11, 2022
PubMed

Insights

Children with attention deficit hyperactivity disorder (ADHD) have lower levels of ciliary neurotrophic factor (CNTF). This study suggests CNTF may play a role in ADHD pathophysiology and could potentially serve as a biomarker.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder.
  • The underlying pathophysiology of ADHD is complex and not fully understood.
  • Ciliary neurotrophic factor (CNTF) is a neurotrophin with potential roles in neuronal development and function.

Purpose of the Study:

  • To investigate the association between ciliary neurotrophic factor (CNTF) and attention deficit hyperactivity disorder (ADHD).
  • To explore the potential of CNTF as a biomarker for ADHD diagnosis and severity.

Main Methods:

  • Prospective recruitment of 6-12-year-old children diagnosed with ADHD and neurotypical controls.
  • Assessment of ADHD symptoms and severity using Conners' Teacher Rating Scale (CTRS).
  • Quantification of serum CNTF levels via enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • A cohort of 43 ADHD patients and 33 healthy controls was analyzed.
  • Significantly lower serum CNTF levels were observed in children with ADHD compared to controls.
  • No significant correlation was found between serum CNTF levels and CTRS scores.

Conclusions:

  • Serum CNTF levels are altered in children with ADHD, indicating a potential link to the disorder's pathophysiology.
  • Lower serum CNTF levels in ADHD patients suggest a possible role in the neurobiological mechanisms underlying ADHD.
  • Further research is warranted to elucidate the precise role and mechanisms of CNTF in ADHD.

Keywords:
Neurodevelopmental disordersbiomarkersdopamineneurochemistryneurotrophins

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