Related Experiment Videos
Torulopsis glabrata osteomyelitis. A case report
Clinical Orthopaedics and Related Research
|June 1, 1987
Summary
Torulopsis glabrata osteomyelitis is a rare skeletal infection. This case highlights successful treatment with 5-fluorocytosine in a patient with a knee arthroplasty complication.
Area of Science:
- Mycology
- Infectious Diseases
- Orthopedic Surgery
Background:
- Skeletal infections are uncommon complications of prosthetic joint surgery.
- Torulopsis glabrata (Candida glabrata) is an opportunistic yeast, rarely implicated in osteomyelitis.
- Prolonged antibiotic therapy can predispose patients to secondary infections.
Observation:
- A 66-year-old woman developed vertebral osteomyelitis.
- The infection occurred postoperatively following total knee arthroplasty for osteoarthritis.
- The patient had received prolonged antibiotics for staphylococcal pneumonia.
Findings:
- Diagnostic imaging revealed a destructive inflammatory lesion of the vertebrae.
- Tissue pathology and culture confirmed Torulopsis glabrata as the causative agent.
- The yeast's pathogenicity in this skeletal site was definitively established.
Implications:
- This case expands the known spectrum of Torulopsis glabrata skeletal infections.
- Successful treatment with 5-fluorocytosine demonstrates its efficacy for this rare condition.
- Early diagnosis and targeted antifungal therapy are crucial for favorable outcomes in yeast-induced osteomyelitis.