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Updated: Jul 11, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
All-In-One Second Near-Infrared Light-Responsive Drug Delivery System for Synergistic Chemo-Photothermal Therapy
Tianxing Zhou1, Shuangcong Xie2, Chunze Zhou3
1Guangdong Medical University, Zhanjiang 524023, P. R. China.
Abstract:
Light-responsive nanocarrier-based drug delivery systems (NDDSs), due to their unique advantages such as safety, minimal cross-reaction, and spatiotemporal precision, have received wide attention. Notably, second near-infrared (NIR-II) light, which has a high penetration depth for manipulating NDDSs to release drugs, is in high demand. Herein, polyethylene glycol (PEG)-modified hollow CuS nanoparticles (NPs) are developed as an all-in-one NIR-II light-responsive NDDS for synergistic chemo-photothermal therapy. First, CuS-PEG NPs were prepared under mild conditions by using Cu2O NPs as sacrificial templates. The morphology, photothermal effect, drug loading/releasing abilities, and synergistic chemo-photothermal therapy of CuS-PEG NPs have been investigated. The CuS-PEG NPs with hollow structures showed a high drug loading capacity (∼255 μg Dox per mg of CuS NPs) and stimuli-responsive drug release triggered by NIR-II laser irradiation. The synergistic chemo-photothermal therapy based on the Dox/CuS-PEG NPs showed 98.5% tumor elimination. Our study emphasizes the great potential of CuS-PEG NPs as an all-in-one NIR-II light-responsive NDDS for applications in biomedicine.
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