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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Sep 5, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Assessing Participant Diversity in Acne Clinical Trials.

Rohit Gupta, Cayla Roy, Hung Doan

    Journal of Drugs in Dermatology : JDD
    |July 11, 2022
    PubMed
    Summary

    Clinical trials lack diversity, especially for minority groups and individuals with skin of color (SOC). Evaluating participant diversity in dermatology trials is crucial for effective, tailored treatments.

    Area of Science:

    • Dermatology
    • Clinical Research
    • Health Equity

    Background:

    • Limited clinical trials focus on treatment protocols for minority groups and individuals with skin of color (SOC).
    • Treatment efficacy and decisions can differ based on patient cultural preferences and skin type.
    • Existing research does not adequately represent diverse populations in dermatology.

    Purpose of the Study:

    • To highlight the need for increased diversity in dermatology clinical trials.
    • To emphasize the importance of evaluating participant representation in studies involving skin of color (SOC).
    • To advocate for inclusive research practices in dermatological treatment development.

    Main Methods:

    • Literature review on existing dermatology clinical trials.

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  • Analysis of participant demographics in published dermatological studies.
  • Assessment of research gaps concerning diverse populations and skin types.

    • Main Results:

    • A significant underrepresentation of minority groups and individuals with skin of color (SOC) in dermatology clinical trials was identified.
    • Lack of data on treatment efficacy across different skin types and cultural backgrounds.
    • Disparities in clinical trial participation hinder the development of equitable dermatological care.

    Conclusions:

    • There is a critical need to enhance diversity in dermatology clinical trials.
    • Future research must prioritize the inclusion of diverse populations, including those with skin of color (SOC).
    • Inclusive clinical trials are essential for advancing dermatological care and ensuring treatment efficacy for all individuals.