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Apparent inconsistent theophylline absorption from sustained release capsules.

D L Uden, D E Schaber, R A Wyatt

    Clinical Pediatrics
    |June 1, 1987
    PubMed
    Summary
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    This study found inconsistent theophylline absorption in children with asthma using Slo-bid Gyrocaps and Theo-dur Sprinkle. This variability complicates accurate asthma medication dosage adjustments for better symptom control.

    Area of Science:

    • Pediatric Pulmonology
    • Clinical Pharmacology
    • Asthma Management

    Background:

    • Sustained-release theophylline improves adherence and asthma control in pediatric patients.
    • Monitoring theophylline serum concentrations is crucial for effective treatment.

    Purpose of the Study:

    • To evaluate theophylline serum concentration variability in pediatric asthma patients.
    • To compare the absorption profiles of Slo-bid Gyrocaps and Theo-dur Sprinkle.

    Main Methods:

    • A randomized crossover study involving 15 children with asthma.
    • Patients received Slo-bid Gyrocaps and Theo-dur Sprinkle for one month each.
    • Theophylline serum concentrations were measured pre-dose and 4 hours post-dose.

    Main Results:

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    • Inconsistent theophylline absorption was observed with both products.
    • Some patients showed lower post-dose than pre-dose concentrations, indicating erratic absorption.
    • Absorption variability ranged from -4.6 mg/L to +10.5 mg/L for Slo-bid Gyrocaps and -2.8 mg/L to +4.9 mg/L for Theo-dur Sprinkle.

    Conclusions:

    • Theophylline absorption from Slo-bid Gyrocaps and Theo-dur Sprinkle can be inconsistent in children.
    • This variability presents challenges for precise dosage adjustments in pediatric asthma management.
    • Further research into optimizing theophylline delivery systems for pediatric asthma is warranted.