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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Sep 5, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

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Exposome Profiles and Asthma among French Adults.

Alicia Guillien¹, Annabelle Bédard², Orianne Dumas²

¹University of Grenoble Alpes, French National Institute of Health and Medical Research, French National Center for Scientific Research, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.

American Journal of Respiratory and Critical Care Medicine

|July 11, 2022

Summary

Early-life exposures like passive smoking and lifestyle factors such as unhealthy diets are linked to adult asthma. Addressing these environmental and lifestyle risk factors is key for asthma prevention.

Keywords:

asthma cluster exposome

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Environmental epidemiology
Public health
Multifactorial disease etiology

Background:

Asthma is a complex, multifactorial disease.
Previous research often focused on single exposures.
A holistic approach considering multiple risk factors is needed.

Purpose of the Study:

To investigate associations between combined exposome factors and asthma phenotypes.
To identify specific risk profiles in early-life and lifestyle domains.
To inform multi-interventional prevention strategies for asthma.

Main Methods:

Utilized data from 20,833 adults in the French NutriNet-Santé cohort.
Assessed 87 exposome factors across socioeconomic, external, early-life, and lifestyle domains.
Employed cluster analysis and regression models to link exposure profiles to asthma outcomes.

Main Results:

Identified specific early-life profiles (e.g., passive smoking, birth parameters) associated with increased asthma symptoms.
Found a lifestyle profile (unhealthy diet, smoking, overweight) linked to more severe asthma.
Reported associations between certain exposure profiles and uncontrolled asthma.

Conclusions:

Early-life and lifestyle-related exposome profiles are significant risk factors for adult asthma.
Findings underscore the need for comprehensive prevention programs.
Interventions should target early-life risk factors and promote healthy adult lifestyles.