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Published on: August 7, 2017
Exposome Profiles and Asthma among French Adults
Alicia Guillien1, Annabelle Bédard2, Orianne Dumas2
1University of Grenoble Alpes, French National Institute of Health and Medical Research, French National Center for Scientific Research, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.
Early-life exposures like passive smoking and lifestyle factors such as unhealthy diets are linked to adult asthma. Addressing these environmental and lifestyle risk factors is key for asthma prevention.
Area of Science:
- Environmental epidemiology
- Public health
- Multifactorial disease etiology
Background:
- Asthma is a complex, multifactorial disease.
- Previous research often focused on single exposures.
- A holistic approach considering multiple risk factors is needed.
Purpose of the Study:
- To investigate associations between combined exposome factors and asthma phenotypes.
- To identify specific risk profiles in early-life and lifestyle domains.
- To inform multi-interventional prevention strategies for asthma.
Main Methods:
- Utilized data from 20,833 adults in the French NutriNet-Santé cohort.
- Assessed 87 exposome factors across socioeconomic, external, early-life, and lifestyle domains.
- Employed cluster analysis and regression models to link exposure profiles to asthma outcomes.
Main Results:
- Identified specific early-life profiles (e.g., passive smoking, birth parameters) associated with increased asthma symptoms.
- Found a lifestyle profile (unhealthy diet, smoking, overweight) linked to more severe asthma.
- Reported associations between certain exposure profiles and uncontrolled asthma.
Conclusions:
- Early-life and lifestyle-related exposome profiles are significant risk factors for adult asthma.
- Findings underscore the need for comprehensive prevention programs.
- Interventions should target early-life risk factors and promote healthy adult lifestyles.
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