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A chitosan and hyaluronic acid-modified layer-by-layer lubrication coating for cardiovascular catheter
Chengxiong Lin1, Zhengyu Huang2, Tingting Wu1
1National Engineering Research Center for Healthcare Devices, Guangdong Provincial Key Laboratory of Medical Electronic Instruments and Polymer Material Products, Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China.
Insights
A new lubricating coating made from hyaluronic acid and chitosan effectively reduces friction and protects blood vessels from damage during cardiovascular catheter procedures. This innovation enhances the safety and utility of transcatheter interventions.
Area of Science:
- Biomaterials Science
- Medical Devices
- Nanotechnology
Background:
- Transcatheter cardiovascular interventions are common but limited by catheter-induced friction damage.
- Developing advanced catheter coatings is crucial for improving procedural safety and efficacy.
Purpose of the Study:
- To design and evaluate a novel layer-by-layer lubricating coating for cardiovascular catheters.
- To assess the coating's ability to reduce friction and prevent vascular injury.
Main Methods:
- A composite coating using dopamine-modified hyaluronic acid (HA-DN) and chitosan (CHI) was fabricated via layer-by-layer assembly.
- The hydrophilic properties, friction reduction (coefficient of friction - COF), and protective effects of the (CHI/HA-DN)8 coating were evaluated.
- Vascular tissue damage was assessed using fluorescent intensity, cell counts, SEM, and histological analysis.
Main Results:
- The CHI/HA-DN coatings exhibited increased hydrophilicity with more deposition layers.
- The (CHI/HA-DN)8 assembly significantly reduced the COF and frictional energy dissipation.
- The coating demonstrated protective effects on aortic tissue, reducing mechanical injury compared to controls.
Conclusions:
- The CHI/HA-DN assembly provides an effective low-damage lubricating coating for cardiovascular catheters.
- This biomaterial offers a promising alternative for enhancing the safety of transcatheter interventions.
Abstract:
Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility. Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work. Results showed that the CHI/HA-DN composite coatings became more hydrophilic as the deposition layers were increased. The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation. Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group. In conclusion, the CHI/HA-DN assembly can provide an alternative selection for low-damage lubricating cardiovascular catheter.
