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Updated: Sep 5, 2025
06:10
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
Published on: March 30, 2020
6.8K
Protein and polypeptide mediated delivery to the eye
Sara Aly Attia1, J Andrew MacKay2
1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
Advanced Drug Delivery Reviews
|July 11, 2022
Summary
Peptide and protein biomaterials offer promising biocompatibility and sustained delivery for ocular conditions. Advanced delivery platforms enhance targeted administration for vision correction and therapeutic applications.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Peptide-based biomaterials, including protein-polymers and antibody-targeted therapeutics, are investigated for ocular conditions.
- These materials show potential for biocompatibility, potency, adaptability, and sustained drug delivery.
- Cellular translation enables precise genetic modification of peptide and protein therapeutics.
Purpose of the Study:
- To review preclinical and clinical opportunities for peptide-based drug delivery to the eye.
- To highlight the benefits of combining local administration with protein specificity for ocular delivery.
- To explore various delivery platforms and administration methods for ocular biomaterials.
Main Methods:
- Review of preclinical and clinical studies on peptide-based ocular drug delivery.
- Analysis of delivery platforms and administration techniques for protein and peptide biomaterials.
- Discussion of genetic engineering applications for therapeutic modification.
Main Results:
- Peptide and protein biomaterials demonstrate significant potential in ocular therapeutics.
- Targeted administration combined with protein specificity enhances ocular drug delivery efficacy.
- Various delivery platforms are being developed for sustained and localized ocular treatment.
Conclusions:
- Peptide-based drug delivery presents a viable strategy for treating diverse ocular conditions.
- Further research into advanced delivery systems can optimize therapeutic outcomes.
- The unique properties of peptides and proteins are well-suited for ocular applications.
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