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Revisiting glucose regulation in birds - A negative model of diabetes complications
1Arizona State University, United States of America.
Abstract:
Birds naturally have blood glucose concentrations that are nearly double levels measured for mammals of similar body size and studies have shown that birds are resistant to insulin-mediated glucose uptake into tissues. While a combination of high blood glucose and insulin resistance is associated with diabetes-related pathologies in mammals, birds do not develop such complications. Moreover, studies have shown that birds are resistant to oxidative stress and protein glycation and in fact, live longer than similar-sized mammals. This review seeks to explore how birds regulate blood glucose as well as various theories that might explain their apparent resistance to insulin-mediated glucose uptake and adaptations that enable them to thrive in a state of relative hyperglycemia.
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