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Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function
Rosario Vicidomini1, Mihaela Serpe1
1Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shiver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Current Topics in Developmental Biology
|July 11, 2022
Summary
Neurons sense synapse activity using local bone morphogenetic protein (BMP) signaling. This BMP signaling acts as a key controller, balancing synapse growth, maturation, and function with other BMP pathways.
Area of Science:
- Neuroscience
- Cell Biology
- Developmental Biology
Background:
- Synapse development relies on communication between pre- and postsynaptic compartments and neuronal activity.
- Neuronal activity modifies synaptic strength to maintain circuit stability despite challenges.
Purpose of the Study:
- To investigate how neurons sense synapse activity.
- To review the role of local BMP signaling as a sensor and controller of synapse activity.
Main Methods:
- Studies conducted at the Drosophila neuromuscular junction (NMJ).
- Analysis of local BMP signaling pathways.
Main Results:
- Local BMP signaling acts as an exquisite sensor for synapse activity at the Drosophila NMJ.
- BMP signaling functions as a key controller, not just a monitor, of synaptic processes.
Conclusions:
- Local BMP signaling is crucial for sensing and regulating synapse activity.
- Coordination with other BMP pathways balances synapse growth, maturation, and function.
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