The relation between coronary artery disease and newly diagnosed dysglycemia
Cam Dinh Truong1, Tung Thanh Ton2
1Cardiovascular Department, Military Hospital 175, Ho Chi Minh, Vietnam.
Insights
Hyperglycemia, including diabetes mellitus and prediabetes, is common in patients with coronary artery disease. Early detection of these glucose metabolism disorders can help predict the risk of coronary syndrome.
Area of Science:
- Cardiology
- Endocrinology
- Metabolic Syndrome
Background:
- A known association exists between hyperglycemia and coronary syndrome.
- Understanding risk factors and clinical manifestations of hyperglycemia in coronary artery disease patients is crucial.
Purpose of the Study:
- To investigate the risk factors and clinical manifestations of hyperglycemia in patients with coronary artery disease.
- To determine the prevalence of diabetes mellitus and prediabetes in patients with metabolic and acute coronary syndrome.
Main Methods:
- A study involving 505 patients in Ho Chi Minh City from 2018-2020.
- Patients were categorized based on glucose tolerance tests: normal metabolism, impaired fasting glucose, and impaired glucose tolerance (including diabetes mellitus).
- Measurements included anthropometrics, hemoglobin HbA1c, glucose, lipids, and creatinine clearance.
Main Results:
- Fasting hyperinsulinemia was significantly associated with increased body weight, BMI, waist circumference, and LAP.
- Decreased insulin sensitivity was observed even in individuals with normal glucose metabolism.
- Diabetes mellitus and prediabetes were more prevalent in patients with metabolic syndrome and acute coronary syndrome.
Conclusions:
- Diabetes mellitus and prediabetes are significant risk factors for metabolic syndrome and acute coronary syndrome.
- The findings aid in predicting coronary syndrome risk based on the presence of diabetes or prediabetes.
- Early identification of glucose metabolism abnormalities is key for cardiovascular risk assessment.
Introduction:
There is a known association between hyperglycemia and the presence of coronary syndrome. The purpose of this work is to study risk factors and clinical manifestations of hyperglycemia in patients diagnosed with coronary artery disease.
Methods:
The study was conducted in 2018-2020 among 505 patients in Ho Chi Minh city, Vietnam. Based on the results of the glucose test at 0 and 120 min, the patients were divided into the groups: with normal glucose metabolism (control, 204), patients with impaired fasting glucose levels (175 patients, group 2), and patients with impaired glucose tolerance, including diabetes mellitus (126, group 3). Anthropometric measurements were performed, and the levels of hemoglobin HbA, glucose, lipids were measured.
Results:
In the group of patients with fasting hyperinsulinemia, all variables (body weight, body mass index, waist circumference, LAP, creatinine clearance) differed considerably as compared to the control group (p ≤ 0.0001). Decrease in tissue sensitivity to insulin is already present at normal levels of glucose metabolism.
Conclusions:
The study found that diabetes mellitus and prediabetes are more typical for patients with metabolic syndrome and acute coronary syndrome. The results obtained will allow predicting the risk of developing coronary syndrome depending on the presence of diabetes mellitus or prediabetes.
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