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Structural insight into apelin receptor-G protein stoichiometry

Yang Yue1, Lier Liu1,2,3, Li-Jie Wu1

  • 1iHuman Institute, ShanghaiTech University, Shanghai, China.

Nature Structural & Molecular Biology
|July 11, 2022
PubMed
Summary

Cryo-electron microscopy revealed the human apelin receptor (APJR) complexed with G proteins in both 2:1 and 1:1 ratios. This stoichiometry influences signaling and pharmacology, highlighting GPCR regulation via oligomerization.

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