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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Accelerated/rush allergen immunotherapy.

Justin Greiwe1, Jonathan A Bernstein1

  • 1From the Bernstein Allergy Group Inc, Cincinnati, Ohio; and.

Allergy and Asthma Proceedings
|July 12, 2022
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Summary
This summary is machine-generated.

Accelerated allergy immunotherapy (IT) offers faster symptom relief and cost savings compared to conventional methods. While risks exist, careful patient selection and premedication ensure safety and efficacy.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Conventional allergy immunotherapy (IT) involves lengthy treatment schedules.
  • Accelerated IT protocols aim to shorten the time to therapeutic dosing for allergens.

Purpose of the Study:

  • To evaluate the efficacy and safety of accelerated immunotherapy (IT) schedules for inhalant and venom allergens.
  • To compare accelerated IT protocols with conventional subcutaneous IT (SCIT).

Main Methods:

  • Review of accelerated immunotherapy (IT) protocols, including rush and cluster schedules.
  • Analysis of mechanisms, risks, and benefits associated with accelerated SCIT.

Main Results:

  • Accelerated IT provides faster allergy symptom relief and improves patient adherence.
  • Reduced direct and indirect costs are associated with accelerated IT due to fewer visits and less travel.
  • The risk of severe systemic reactions is low but necessitates careful patient screening and premedication.

Conclusions:

  • Accelerated SCIT regimens offer convenience, faster symptom improvement, and potential cost reductions.
  • Equivalent safety outcomes can be achieved with accelerated IT compared to conventional protocols when administered appropriately.
  • Excluding high-risk individuals (e.g., those with uncontrolled asthma or on beta-blockers) is crucial for mitigating reaction risks.