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Updated: Sep 5, 2025
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Supramolecular Hydrogel Based on Pseudopolyrotaxane Aggregation for Bacterial Microenvironment-Responsive Antibiotic
Rui Zhang1, Xiaoyang Liang1, Jia Wang1
1State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, 100029, Beijing, P. R. China.
This study introduces a novel supramolecular hydrogel for antibiotic delivery. The pH-sensitive hydrogel effectively releases antibiotics in response to infection, showing potent antimicrobial activity and biocompatibility.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Antimicrobial Research
Background:
- Rising antibiotic resistance poses a significant global health threat.
- Effective and rational antibiotic delivery is crucial for combating resistant pathogens.
Purpose of the Study:
- To develop a novel supramolecular hydrogel for controlled antibiotic delivery.
- To investigate the pH-responsive drug release and antimicrobial efficacy of the hydrogel.
Main Methods:
- Fabrication of a supramolecular hydrogel using pseudopolyrotaxanes aggregation.
- Incorporation of pH-sensitive imine bonds for controlled drug release.
- Antimicrobial assessments against Gram-positive and Gram-negative bacteria.
Main Results:
- The hydrogel demonstrated efficient antibiotic encapsulation and release under mild conditions.
- pH-sensitive imine bonds facilitated reversible changes in crosslink density, controlling antibiotic release.
- Effective antimicrobial activity was observed, with a burst release in acidic (infected) environments.
- Excellent biocompatibility was confirmed for potential biomedical applications.
Conclusions:
- The developed supramolecular hydrogel offers a promising platform for targeted antibiotic delivery.
- Its pH-responsive nature and biocompatibility highlight its potential in combating drug-resistant infections.
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