Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microcore Skin Biopsies: A Novel, Micro-Invasive Skin Biopsy Technique Yielding Full-Thickness Histology.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026

Same author

Novel 1550-nm Nonablative Resurfacing Laser With Focal Point Technology Improves Fine Lines and Wrinkles With High Energy Delivery.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026

Same author

Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cutaneous melanoma.

Frontiers in medicine·2026

Same author

An Optimized Staining Method for Visualization of Thermally Denatured Dermal Collagen.

Lasers in surgery and medicine·2026

Same author

Optical coherence tomography and histological assessment of cutaneous vasculature and neural changes in long-term smokers: an exploratory study.

Scientific reports·2026

Same author

Prevalence of vestibular pathology in patients with congenital inner ear malformation.

International journal of pediatric otorhinolaryngology·2026

Search research articles

Related Experiment Video

Updated: Sep 5, 2025

Author Spotlight: Exploring Orofacial Muscle Regeneration – Insights and Innovations

Author Spotlight: Exploring Orofacial Muscle Regeneration – Insights and Innovations

Published on: December 29, 2023

Mouse model of selective cryolipolysis.

Nunciada Salma¹, Michael Wang-Evers¹, Malte Johannes Casper²

¹Department of Dermatology, Cutaneous Biology Research Center (CBRC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Lasers in Surgery and Medicine

|July 12, 2022

Summary

This summary is machine-generated.

A novel mouse model for cryolipolysis demonstrates effective, targeted fat reduction using controlled cooling. This research validates cryolipolysis

Keywords:

cryolipolysis fat reduction mouse model noninvasive panniculitis

More Related Videos

Cryosectioning of Contiguous Regions of a Single Mouse Skeletal Muscle for Gene Expression and Histological Analyses

Cryosectioning of Contiguous Regions of a Single Mouse Skeletal Muscle for Gene Expression and Histological Analyses

Published on: December 12, 2016

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Sep 5, 2025

Author Spotlight: Exploring Orofacial Muscle Regeneration – Insights and Innovations

Author Spotlight: Exploring Orofacial Muscle Regeneration – Insights and Innovations

Published on: December 29, 2023

Cryosectioning of Contiguous Regions of a Single Mouse Skeletal Muscle for Gene Expression and Histological Analyses

Cryosectioning of Contiguous Regions of a Single Mouse Skeletal Muscle for Gene Expression and Histological Analyses

Published on: December 12, 2016

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

Area of Science:

Dermatology and cosmetic science
Biomedical engineering
Cell biology

Background:

Cryolipolysis is a noninvasive technique that selectively destroys adipocytes through controlled cooling.
This method targets localized fat reduction by exploiting adipocytes' vulnerability to cold.

Observation:

A new, miniaturized cryolipolysis mouse model was developed for reproducible fat reduction studies.
Optical coherence tomography (OCT) and histological analyses quantified subcutaneous fat changes post-treatment.

Findings:

Cryolipolysis treatment in mice significantly reduced subcutaneous fat thickness compared to controls.
Histological analysis revealed selective adipocyte damage and immune cell infiltration, characteristic of cold panniculitis, without skin injury.

Implications:

The developed mouse model offers a cost-effective, efficient platform for studying cryolipolysis mechanisms and validating clinical hypotheses.
Further research using this model can enhance understanding of fat cell apoptosis and optimize clinical outcomes for noninvasive body contouring.