Tremor-like grasp phenomenon: case series study

Area of Science:

• Neurology
• Movement Disorders
• Neuroscience

Background:

• The grasp phenomenon, characterized by grasp reflex and instinctive grasping, is rarely associated with tremor-like movements.
• This study investigates a specific presentation of abnormal movements linked to the grasp phenomenon.

Purpose of the Study:

• To clinically and neuroradiologically characterize tremor-like movements associated with the grasp phenomenon.
• To explore the underlying pathophysiology and potential neurological correlates of this rare condition.

Main Methods:

• Clinical assessment of four patients presenting with tremor-like movements and grasp phenomenon.
• Neuroradiological investigations including MRI and CT scans to identify potential brain lesions.
• Detailed analysis of movement characteristics, onset, and associated neurological signs.

Main Results:

• Four female patients (aged 61-98) exhibited stereotypic, rhythmic, tremor-like movements, often with groping/picking actions.
• All patients displayed the grasp phenomenon (reflex or instinctive grasping) ipsilateral to the movements.
• Associated findings included cerebral infarcts (n=2), meningioma (n=1), or history of focal seizures (n=1).

Conclusions:

• The observed tremor-like movements are a distinct variation of the grasp phenomenon, termed "tremor-like grasp phenomenon."
• These movements are likely caused by hyperexcitation of the frontal lobe contralateral to the affected side.
• The findings highlight a novel presentation of the grasp phenomenon with potential implications for understanding frontal lobe dysfunction.