Related Experiment Video

Updated: Sep 5, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.7K

Incidence trends and survival analysis of atypical meningiomas: a population-based study from 2004 to 2018

Matthew J Recker1,2, Cathleen C Kuo3, Dheerendra Prasad1,2,4,5

  • 1Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.

Journal of Neuro-Oncology
|July 12, 2022
PubMed
Abstract

Insights

The incidence of atypical meningioma is increasing faster than all meningiomas. Continued monitoring and improved outcomes for atypical meningioma patients are crucial due to this rising trend.

Area of Science:

  • Neuro-oncology
  • Epidemiology
  • Cancer Research

Background:

  • Atypical meningiomas present intermediate features between benign and malignant types.
  • The incidence trends of atypical meningiomas, particularly concerning World Health Organization (WHO) classification changes, require further investigation.

Purpose of the Study:

  • To analyze the incidence trends of atypical meningiomas in comparison to all meningiomas.
  • To evaluate survival rates and identify prognostic factors for atypical meningioma patients.

Main Methods:

  • Utilized the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database (2004-2018).
  • Calculated age-adjusted incidence rates and annual percent change (APC) using joinpoint regression.
  • Analyzed survival using Kaplan-Meier method and Cox proportional hazards models.

Main Results:

  • Atypical meningioma incidence increased significantly faster (APC 5.6%) than all meningiomas (APC 2.5%).
  • 1, 3, 5, and 10-year survival rates for atypical meningiomas were 91.9%, 81.3%, 68.8%, and 34.3%, respectively.
  • Male sex, older age (≥60 years), and large tumor size (>5 cm) were independent risk factors for poor prognosis.

Conclusions:

  • Atypical meningioma incidence is rising relative to all meningiomas.
  • Ongoing surveillance of atypical meningioma incidence and mortality is essential to confirm persistent uptrends.
  • Enhanced efforts to improve outcomes for atypical meningioma patients are necessary given the increasing incidence.
Keywords:
Atypical meningiomaEpidemiologyNeuro-oncologyWorld Health Organization (WHO) grade

More Related Videos

Translational Orthotopic Models of Glioblastoma Multiforme07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

3.0K
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma10:58

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

13.0K

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
442
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
766
Actuarial Approach01:20

Actuarial Approach

The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
129
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
276