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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

189
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
189
Antibiotic Selection00:57

Antibiotic Selection

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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[The postal code as a "bar code" of antimicrobial resistance].

P Galicia1, M Linares, A Miguel-Benito

  • 1Hospital Universitario Príncipe de Asturias. Servicio de Microbiología Clínica. Carretera de Alcalá, s/n, 28805 Meco (Madrid). Spain. pilarteresa.galicia@salud.madrid.org.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|July 12, 2022
PubMed
Summary
This summary is machine-generated.

Local Neisseria gonorrhoeae (N. gonorrhoeae) resistance data is crucial for effective primary care. Half of isolates were ciprofloxacin-resistant, highlighting the need for updated empirical treatment guidelines to combat rising antimicrobial resistance.

Keywords:
BacterialDrug ResistanceNeisseria gonorrhoeaeSocial Determinants of Health

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Area of Science:

  • Microbiology
  • Public Health
  • Clinical Medicine

Background:

  • Antimicrobial resistance in Neisseria gonorrhoeae (N. gonorrhoeae) poses a significant global health threat.
  • Empirical antibiotic treatment is common in primary care settings, necessitating knowledge of local resistance patterns.

Purpose of the Study:

  • To analyze the sociodemographic characteristics and antimicrobial resistance patterns of N. gonorrhoeae isolates in Alcalá de Henares.
  • To provide data supporting the integration of local resistance information into clinical practice, particularly in primary care.

Main Methods:

  • Retrospective observational study of 256 N. gonorrhoeae isolates from various anatomical sites.
  • Analysis of resistance to cephalosporins, azithromycin, penicillin, and quinolones.
  • Spatial mapping of antimicrobial resistance using postal code data.

Main Results:

  • The study included 256 N. gonorrhoeae isolates, predominantly from males (92.9%) with a mean age of 33 years.
  • A high rate of resistance to ciprofloxacin was observed, with 49.8% of isolates showing resistance.
  • Heat maps visualized the temporal and spatial distribution of antimicrobial resistance.

Conclusions:

  • Understanding local antimicrobial resistance profiles is essential for optimizing empirical treatment strategies in primary care.
  • Informed prescribing can reduce the use of inadequate antibiotics, thereby mitigating the spread of N. gonorrhoeae resistance.