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Updated: Sep 5, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Association between serum calcium and in-hospital mortality in critical patients with multiple myeloma: a cohort

Yafei Mao1, Shumin Zhu1, Yulan Geng1

  • 1Department of Laboratory Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|July 12, 2022
PubMed

Insights

Serum calcium levels show a nonlinear association with mortality in critically ill multiple myeloma (MM) patients. Levels around 8.40 mg/dL correlate with the lowest risk, with higher levels increasing mortality risk.

Area of Science:

  • Critical Care Medicine
  • Oncology
  • Clinical Biomarkers

Background:

  • Elevated serum calcium is a potential biomarker for mortality in multiple myeloma (MM).
  • The specific relationship between serum calcium and in-hospital mortality in critically ill MM patients is not well-defined.

Purpose of the Study:

  • To investigate the association between serum calcium levels and in-hospital mortality in intensive care unit (ICU) patients with MM.

Main Methods:

  • Utilized the MIMIC-IV database to identify MM patients admitted to the ICU.
  • Employed multivariable-adjusted Cox regression, curve fitting, and threshold effects analysis.
  • Assessed the relationship between serum calcium levels and in-hospital mortality.

Main Results:

  • Included 262 MM patients (mean age 72.3 years, 63.4% male); in-hospital mortality was 19.5%.
  • A nonlinear relationship was observed between serum calcium levels and in-hospital mortality.
  • The lowest risk of mortality was associated with serum calcium around 8.40 mg/dL, with increased risk at higher levels.

Conclusions:

  • A nonlinear association exists between serum calcium and in-hospital mortality in critically ill MM patients.
  • Serum calcium levels around 8.40 mg/dL are linked to the lowest mortality risk.
  • ICU physicians should monitor rising serum calcium levels in MM patients due to increased mortality risk.
Abstract

Keywords:
Multiple myelomain-hospital mortalityintensive care unitserum calcium levels

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