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Updated: Sep 5, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
Published on: May 3, 2024
Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond
Andrew L O'Brien1, Julie M West1, Tiam M Saffari1
1Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Abstract:
Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the central nervous system, peripheral nerves have the ability to regenerate lost axons after injury; however, axonal regeneration does not equate to full restoration of function. To overcome this physiological shortcoming, advances in nerve regeneration and repair are paramount, including electrical stimulation, gene therapy, and surgical technique advancements.
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