Related Experiment Video
Updated: Sep 5, 2025

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
Published on: February 17, 2015
Pacemaker lead-related endocarditis with Neisseria sicca
Margaret Locke1, Alexander Smith2, Laurence M Epstein3
1Department of Internal Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York, USA maggielwo@yahoo.com.
This case study details a rare pacemaker lead endocarditis caused by Neisseria sicca. Early detection and device extraction led to complete patient recovery.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Device Infections
Background:
- Pacemaker lead endocarditis is an increasingly recognized complication.
- Prompt diagnosis and intervention are crucial for favorable outcomes.
Observation:
- A woman in her 70s presented with recurrent fevers after pacemaker placement.
- Blood cultures identified Neisseria sicca, and echocardiography revealed vegetations on the pacemaker lead.
Findings:
- The patient was diagnosed with Neisseria sicca-associated pacemaker lead endocarditis.
- Complete pacemaker and lead extraction was successfully performed.
Implications:
- This case highlights the importance of considering device infections in patients with pacemakers and fever.
- Earlier identification and treatment of pacemaker lead endocarditis can improve patient prognosis.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis IV: Nursing Management
Endocarditis III: Medical Management
Pericarditis I: Introduction
Rheumatic Heart Disease I: Introduction

