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Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
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The P2X1 receptor as a therapeutic target

Felix M Bennetts1, Jesse I Mobbs1, Sabatino Ventura1

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.

Purinergic Signalling
|July 13, 2022
PubMed
Summary

The P2X1 receptor, a target for male contraception and bladder dysfunction, shows promise for treating thrombosis and inflammation. New small molecule antagonists require further validation for drug development.

Keywords:
ATPBladder dysfunctionDrug discoveryMale contraceptionStructural biologyThrombosis and inflammation

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