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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Author Spotlight: Optimizing Apoplast Protein Extraction for Efficient Recovery of Recombinant Proteins from Plant Cells
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Plant-Derived Human Vaccines: Recent Developments.

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Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
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Plant-based vaccines, or biopharming, have advanced significantly. This review covers recent progress in producing plant-derived vaccines for human use, focusing on improved expression and efficacy.

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Area of Science:

  • Biotechnology
  • Molecular Farming
  • Vaccinology

Background:

  • Plant-based vaccine production emerged in the late 1980s, initially exploring edible vaccine concepts.
  • Challenges with expression, dosage, and regulation led to a shift towards parenteral plant-produced vaccines.
  • Advancements include transient expression, refined purification, and demonstrated immunogenicity, establishing biopharming.

Purpose of the Study:

  • To review recent advancements in plant-based vaccine production for human applications.
  • To highlight the evolution from edible to parenteral vaccine candidates.
  • To discuss the current state and acceptance of plants as a vaccine production platform.

Main Methods:

  • Review of scientific literature on plant molecular farming for vaccine development.
  • Analysis of improved expression techniques (transgenic to transient).
  • Evaluation of purification protocols and immunogenicity studies.

Main Results:

  • Successful development of subunit and nanoparticle vaccine candidates targeting various diseases.
  • Demonstrated immunogenicity and efficacy of plant-produced vaccine candidates.
  • Increased acceptance of plants as a viable platform for vaccine manufacturing.

Conclusions:

  • Biopharming has matured into a reliable technology for vaccine production.
  • Plants offer a cost-effective and accessible platform for developing diverse vaccine types.
  • Ongoing research continues to refine plant-based vaccine development for human health.