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Updated: Sep 5, 2025
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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Cellular Senescence and Ageing: Mechanisms and Interventions
Andreas Mylonas1, Ana O'Loghlen1
1Epigenetics & Cellular Senescence Group, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Frontiers in Aging
|July 13, 2022
Summary
Cellular senescence, a state of irreversible growth arrest, is increasingly linked to aging and related diseases. Understanding senescence triggers and its impact on tissues is crucial for developing senolytic therapies.
Area of Science:
- Gerontology and Cellular Biology
- Molecular Biology and Genetics
Background:
- Cellular senescence, a key biological process, plays a significant role in aging and age-related diseases.
- Therapeutic strategies targeting senescent cells, known as senolytics, are under development to combat these conditions.
- A deeper understanding of senescence activation and its tissue-specific effects is essential.
Purpose of the Study:
- To elucidate the general triggers and characteristics of cellular senescence.
- To describe the influence of senescent cells on the aging process.
- To explore the role of senescent cells in various age-related diseases.
Main Methods:
- Literature review and synthesis of existing research on cellular senescence.
- Analysis of molecular pathways and cellular events leading to senescence.
- Review of studies investigating the impact of senescent cells in aging and disease models.
Main Results:
- Senescence is triggered by various stressors, leading to distinct cellular phenotypes.
- Senescent cells accumulate with age and contribute to tissue dysfunction.
- Evidence links senescent cells to the pathogenesis of multiple age-related diseases, including fibrosis, cancer, and neurodegeneration.
Conclusions:
- Cellular senescence is a fundamental mechanism in aging and disease.
- Targeting senescent cells with senolytics holds therapeutic promise for age-related conditions.
- Further research is needed to fully understand senescence regulation and its precise roles in different tissues.
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