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Updated: Sep 5, 2025

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
Published on: June 14, 2020
Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
Himangi Srivastava1,2, Marina Pozzoli1,2, Edward Lau1,2
1Department of Medicine/Cardiology, School of Medicine, University of Colorado, Aurora, CO, United States.
Abstract:
In recent years an expanding collection of heart-secreted signaling proteins have been discovered that play cellular communication roles in diverse pathophysiological processes. This minireview briefly discusses current evidence for the roles of cardiokines in systemic regulation of aging and age-associated diseases. An analysis of human transcriptome and secretome data suggests the possibility that many other cardiokines remain to be discovered that may function in long-range physiological regulations. We discuss the ongoing challenges and emerging technologies for elucidating the identity and function of cardiokines in endocrine regulations.
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