Related Experiment Video

Updated: Sep 5, 2025

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
11:53

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart

Published on: June 14, 2020

7.6K

Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases

Himangi Srivastava1,2, Marina Pozzoli1,2, Edward Lau1,2

  • 1Department of Medicine/Cardiology, School of Medicine, University of Colorado, Aurora, CO, United States.

Frontiers in Aging
|July 13, 2022
PubMed

Insights

Newly discovered heart-secreted proteins, cardiokines, regulate aging and related diseases. Further research into these signaling proteins may reveal new long-range physiological functions and therapeutic targets.

Area of Science:

  • Cardiology and endocrinology
  • Molecular biology and genetics

Background:

  • Heart-secreted signaling proteins, known as cardiokines, are increasingly recognized for their roles in cellular communication.
  • These proteins are implicated in various pathophysiological processes, including aging and associated diseases.

Purpose of the Study:

  • To review current evidence on the roles of cardiokines in the systemic regulation of aging and age-associated diseases.
  • To explore the potential for undiscovered cardiokines involved in long-range physiological regulations.
  • To discuss challenges and technologies for identifying and understanding cardiokine function in endocrine regulation.

Main Methods:

  • Analysis of human transcriptome and secretome data.
  • Literature review of existing evidence on cardiokine function.

Main Results:

  • Evidence suggests cardiokines play a role in systemic regulation of aging.
  • Human data analysis indicates the existence of numerous undiscovered cardiokines with potential long-range functions.

Conclusions:

  • Cardiokines represent a significant area for future research in aging and endocrine regulation.
  • Emerging technologies are crucial for identifying and characterizing novel cardiokines and their functions.

Keywords:
agingcardiokineendocrinehearthiPSCproteomicssecretometranscriptomics

More Related Videos

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes09:17

Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes

Published on: October 10, 2020

9.4K
Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

22.1K

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.3K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
165
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
30
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.5K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
790