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mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Marti Cadena Sandoval1,2, Alexander Martin Heberle1,2, Ulrike Rehbein1

  • 1Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.

Frontiers in Aging
|July 13, 2022
PubMed

Insights

The mechanistic target of rapamycin complex 1 (mTORC1) kinase regulates metabolism and aging. Aging stressors impact mTORC1 and stress granules (SGs), influencing age-related diseases.

Area of Science:

  • Cellular Biology
  • Aging Research
  • Molecular Mechanisms

Background:

  • The mechanistic target of rapamycin complex 1 (mTORC1) is a key regulator of cellular metabolism and aging.
  • Aging is characterized by declining cellular functions and increased susceptibility to stressors.
  • Stress granules (SGs) are dynamic RNA-protein aggregates involved in cellular stress response.

Purpose of the Study:

  • To review the impact of aging hallmarks on mTORC1 signaling.
  • To explore the role of stress granules (SGs) in cellular aging.
  • To elucidate the interplay between mTORC1 and SGs in the context of aging and age-related diseases.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of signaling pathways involving mTORC1 and SGs.
  • Discussion of molecular mechanisms linking aging, mTORC1, and SGs.

Main Results:

  • Aging hallmarks induce cellular stress that affects both mTORC1 and SGs.
  • There is a complex crosstalk between the mTORC1 network and SGs.
  • This interplay contributes to age-related cellular dysfunction and disease.

Conclusions:

  • Understanding the mTORC1-SG axis is crucial for aging research.
  • Targeting this axis may offer therapeutic strategies for age-related diseases.
  • Further research is needed to fully unravel the implications of this crosstalk.
Keywords:
MTORaging hallmarksamino acidsautophagycellular signalinginsulinstressstress granules (SGs)

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