Effects of Hyperoxia on Aging Biomarkers: A Systematic Review
Belay Tessema1,2,3, Ulrich Sack1, Zoya Serebrovska4
1Institute of Clinical Immunology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Frontiers in Aging
|July 13, 2022
Summary
Short-term hyperoxia shows potential benefits for age-related diseases and aging biomarkers by increasing antioxidant enzymes and telomere length. Further research is needed to optimize its clinical application and minimize side effects.
Area of Science:
- Gerontology and Cellular Biology
- Biomedical Science
- Oxygen Therapy Research
Background:
- Conflicting findings exist regarding short-term hyperoxia's effects on aging and related diseases.
- Existing research utilizes diverse protocols, complicating interpretation.
- A systematic review is needed to consolidate current evidence.
Purpose of the Study:
- To systematically review the effects of short-term hyperoxia on age-related diseases and aging biomarkers.
- To analyze impacts on key factors like HIF-1α, telomere length, and cellular senescence.
- To evaluate reported side effects of hyperoxia treatments.
Main Methods:
- Systematic literature search following PRISMA guidelines.
- Databases searched: PubMed, Google Scholar, Cochrane Library.
- Inclusion criteria: Studies on short-term hyperoxia, aging, and related biomarkers; 17 studies selected from 1,699.
Main Results:
- Most studies indicate significant effects of short-term hyperoxia on aging biomarkers and diseases.
- Hyperoxia influences transcription factors (HIF-1α, NF-kB, NRF2), antioxidant enzymes, telomere length, and senescent cell clearance.
- Potential benefits include improved cognitive function and applications in critical care, but dose-dependent adverse effects like DNA damage are noted.
Conclusions:
- Short-term hyperoxia presents a feasible therapeutic option for age-related diseases and slowing aging.
- Benefits include enhanced antioxidant capacity, increased telomere length, senescent cell clearance, and cognitive improvement.
- Further studies are essential to fully understand benefits and mitigate risks for optimal clinical use.
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