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Related Concept Videos

Gallbladder01:17

Gallbladder

872
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
872
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

941
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
941
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

285
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
285

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Incidental Gallbladder Neoplasms: A Growing Global Burden.

Neha Singh1, Ariba Zaidi1, Rupinder Kaur1

  • 1Pathology, Maharishi Markandeshwar Institute of Medical Science and Research, Ambala, IND.

Cureus
|July 13, 2022
PubMed
Summary

Histopathological evaluation of cholecystectomies frequently reveals incidental gallbladder malignancies. Thorough examination is crucial, as these cancers often present with non-specific imaging findings, masquerading as benign conditions.

Keywords:
cholecystectomiesgallstonehistopathologyincidental gallbladder carcinomaradiology

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Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Oncology

Background:

  • Cholecystectomies are common surgical procedures, leading to increased detection of incidental gallbladder malignancies.
  • Laparoscopic surgery trends contribute to the high volume of gallbladder specimens examined histopathologically.

Purpose of the Study:

  • To describe the histopathological spectrum of gallbladder neoplastic lesions.
  • To correlate imaging findings with histopathology, focusing on incidental gallbladder carcinomas (IGBC).

Main Methods:

  • Analysis of 1253 cholecystectomy specimens over 2.5 years.
  • Detailed recording of demographic, imaging, gross, and microscopic findings.
  • Utilized special stains as needed for diagnosis.

Main Results:

  • 50 cases (3.9%) showed neoplastic pathology; 28 invasive malignancies (56%), including 11 IGBC (22%).
  • Dysplasia found in 21 cases (42%); adenocarcinoma (pancreaticobiliary type) was most common.
  • Ultrasonography showed non-specific wall thickening; gallstones present in 74%.

Conclusions:

  • Gallbladder cancer (GBC) is often diagnosed incidentally, presenting a diagnostic challenge.
  • Preoperative diagnosis of GBC is not definitive, with IGBC often disguised radiologically.
  • Meticulous histopathological examination of all cholecystectomy specimens is essential for accurate diagnosis and patient management.