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Published on: February 26, 2013
Long-Term Outcomes of Preoperative Atrial Fibrillation in Cardiac Surgery
Hyo-Hyun Kim1, Ji-Hong Kim1, Sak Lee1
1Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.
Insights
Preoperative atrial fibrillation (Afib) increases mortality risk after cardiac surgery. However, performing Cox-maze surgery concurrently with cardiac procedures may improve survival rates for Afib patients.
Area of Science:
- Cardiology
- Cardiac Surgery
- Epidemiology
Background:
- Atrial fibrillation (Afib) is a significant predictor of cardiovascular complications.
- Afib is prevalent in patients undergoing cardiac surgery, necessitating an understanding of its impact on outcomes.
- Assessing the effect of preoperative Afib on postsurgical results is crucial.
Purpose of the Study:
- To investigate the association between preoperative atrial fibrillation and clinical outcomes in patients undergoing cardiac surgery.
- To analyze the impact of Afib on mortality and other adverse events post-cardiac surgery.
- To evaluate the potential benefit of specific surgical interventions, like Cox-maze surgery, in mitigating Afib-related risks.
Main Methods:
- Retrospective cohort study utilizing the Korean National Health Insurance Service database (2009-2015).
- Inclusion of 1,022 patients who underwent cardiac surgery, with analysis of preoperative atrial fibrillation status.
- Statistical analysis including hazard ratios and confidence intervals to determine risk associations.
Main Results:
- Preoperative atrial fibrillation was linked to increased patient mortality (p=0.028) irrespective of surgical procedure.
- Patients with preoperative Afib (18.6%) faced a higher cumulative risk of overall mortality (HR, 1.435; p=0.034).
- Cox-maze surgery demonstrated a reduced risk of overall mortality in Afib patients (HR, 0.500; p=0.031), while postoperative cerebral events were not associated with Afib.
Conclusions:
- Preoperative atrial fibrillation is an independent predictor of poorer long-term outcomes following cardiac surgery.
- Concurrent Cox-maze surgery may enhance survival rates in patients with atrial fibrillation undergoing cardiac procedures.
- Further research may explore optimized surgical strategies for Afib patients.
Background:
Atrial fibrillation (Afib) is a marker of increased cardiovascular morbidity and mortality. Owing to the increased prevalence of Afib in patients undergoing cardiac surgery, assessing the effect of Afib on postsurgical outcomes is important. We aimed to analyze the effect of preoperative Afib on clinical outcomes in patients undergoing cardiac surgery using a large surgical database.
Methods:
This retrospective cohort study was based on the national health claims database established by the National Health Insurance Service of the Republic of Korea from 2009 to 2015. Diagnosis and procedure codes were used to identify diseases according to the International Statistical Classification of Diseases, 10th revision.
Results:
We included 1,037 patients (0.1%) who had undergone cardiac surgery from a randomized 1,000,000-patient cohort, and 15 patients (1.5%) treated with isolated surgical Afib ablation were excluded. Of these 1,022 patients, 412 (39.7%), 303 (29.2%), and 92 (9.0%) underwent coronary artery bypass, heart valve surgery, and Cox-maze surgery, respectively. Preoperative Afib was associated with higher patient mortality (p=0.028), regardless of the surgical procedure. Patients with preoperative Afib (n=190, 18.6%) experienced a higher cumulative risk of overall mortality (hazard ratio [HR], 1.435; 95% confidence interval [CI], 1.263-2.107; p=0.034). Subgroup analysis revealed a reduced risk of overall mortality with Cox-maze surgery in Afib patients (HR, 0.500; 95% CI, 0.266-0.938; p=0.031). Postoperative cerebral ischemia or hemorrhage events were not related to Afib.
Conclusion:
Preoperative Afib was independently associated with worse long-term postoperative outcomes after cardiac surgery. Concomitant Cox-maze surgery may improve the survival rate.
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