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Updated: Sep 5, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
C-H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular
Daniel S Brandes1, Jonathan A Ellman1
1Department of Chemistry, Yale University, 225 Prospect St., New Haven, Connecticut 06520, USA. jonathan.ellman@yale.edu.
Sequential multicomponent C-H bond addition reactions rapidly build molecular complexity. These reactions efficiently transform C-H bonds into valuable compounds with precise control, offering vast discovery potential.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Sequential multicomponent C-H bond addition reactions are key for modular synthesis.
- These reactions involve adding C-H bonds across π-bonds or isosteres, followed by coupling to form two new σ-bonds.
Purpose of the Study:
- To review the development and scope of sequential C-H bond addition reactions.
- To highlight the efficiency, control, and potential for new discoveries in this field.
Main Methods:
- Review of existing literature on sequential C-H bond addition reactions.
- Analysis of reaction mechanisms, scope, and applications.
Main Results:
- Demonstration of atom-economical transformations of C-H bonds under mild conditions.
- Achieved high levels of regiochemical and stereochemical control in product formation.
- Elucidation of diverse mechanisms and surprising molecular connectivities.
Conclusions:
- Sequential C-H bond addition reactions offer a powerful platform for generating molecular complexity.
- The vast combinatorial possibilities promise numerous opportunities for discovering novel reactions and applications.
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