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The Clinical Approach toward Hereditary Persistence of Fetal Hemoglobin: A Case Report

Afshin Ghaderi1, Tahereh Bakhtiari2, Saeid Jokar3

  • 1Department of Internal Medicine, Hematology and Medical Oncology Ward, Yasuj University of Medical Sciences, Yasuj, Iran. afshin.ghaderi@yahoo.com.

Iranian Journal of Allergy, Asthma, and Immunology
|July 13, 2022
PubMed

Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin. A steady increase of HbF in patients with hereditary persistence of fetal hemoglobin (HPFH) is associated with complications. The present report describes HPFH in a 26-year-old man with emphasis on its hemoglobin electrophoresis. The patient was admitted with complaints of recurrent weakness and lethargy, weight loss, abdominal pain, and dyspepsia. Splenectomy was planned due to massive splenomegaly and gastrointestinal complications. Ultimately,  electrophoresis confirmed the diagnosis of HPFH.

Keywords:
Blood protein electrophoresisFetal hemoglobinHemoglobinopathies

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