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Three pediatric cases of symptomatic hyponatremia in Prader-Willi syndrome
Yuji Oto1, Nobuyuki Murakami1, Ryo Nakagawa2
1Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
Objectives:
A recent large retrospective cohort study of cases of hyponatremia in Prader-Willi syndrome (PWS), conducted at nine reference centers, showed that severe hyponatremia was rare in PWS (0.5%); furthermore, all cases involved adults. Here, we describe three pediatric cases of severe hyponatremia in PWS, with neurological symptoms.
Case Presentation:
The cases involved two girls and one boy, and only one patient showed uniparental disomy. All patients had hyponatremia during infancy and presented with clinical symptoms, such as convulsions. All three patients improved with intravenous fluids and fluid restriction, with no sequelae.
Conclusions:
We report three pediatric cases of symptomatic hyponatremia of unknown cause in PWS. In patients with PWS, especially those with neurological symptoms such as convulsions, it is necessary to take hyponatremia into consideration.
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