Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inferior collicular interactions with limbic seizure activity.

T J McCown, R S Greenwood, G R Breese

    Epilepsia
    |May 1, 1987
    PubMed
    Summary

    Investigating inferior colliculus (IC) stimulation, this study found that repetitive IC activity alters amygdala kindling, impacting seizure progression and generalization. These findings offer insights into brain region interactions in epilepsy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism.

    Gene therapy·2016
    Same author

    Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates.

    Gene therapy·2013
    Same author

    The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.

    Gene therapy·2011
    Same author

    Delivering multiple gene products in the brain from a single adeno-associated virus vector.

    Gene therapy·2009
    Same author

    Cerebellar cGMP varies with motor function and respiratory gas exchange.

    Neuroscience letters·2009
    Same author

    Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo.

    Gene therapy·2007

    Area of Science:

    • Neuroscience
    • Epileptology

    Background:

    • Seizure activity in the inferior colliculus (IC) can spread to forebrain regions.
    • The interaction between the IC and the amygdala in seizure activity is not well understood.

    Purpose of the Study:

    • To investigate potential interactions between the inferior colliculus and the amygdala regarding seizure activity.
    • To understand how IC stimulation affects amygdala kindling and seizure generalization.

    Main Methods:

    • Acute and repetitive electrical stimulation of the inferior colliculus in animal models.
    • Electrophysiological recordings of amygdala EEG activity.
    • Assessment of seizure progression and behavioral changes during amygdala kindling.
    • Pharmacological evaluation of seizure generalization using diazepam and carbamazepine.

    Main Results:

    • Repetitive IC stimulation led to postictal spiking in the amygdala, resembling amygdala kindling, but without observable behavioral changes.
    • Prior IC stimulation significantly increased the number of stimulations required for amygdala kindling to reach class 5 seizures.
    • Animals with prior IC stimulation exhibited wet-dog shakes during amygdala kindling, unlike controls.
    • Diazepam and carbamazepine blocked seizure generalization behaviors originating from the IC, suggesting a distinct mechanism from acute seizure activity.

    Conclusions:

    • Repetitive inferior collicular stimulation profoundly influences amygdala kindling and seizure generalization.
    • The findings suggest distinct mechanisms underlying acute seizure activity and seizure generalization from the IC.
    • This research contributes to understanding complex neural network interactions in epilepsy.

    Related Experiment Videos