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Dyslipidemia is insufficiently treated in antiphospholipid syndrome patients

Cécile M Yelnik1,2, Claire Martin3, Emmanuel Ledoult1,4

  • 127023University of Lille, CHU Lille, Département de Médecine Interne et d'Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares Nord et Nord-Ouest de France (CeRAINO), European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network (ReCONNECT), Lille, France.

Lupus
|July 13, 2022
PubMed

Insights

Dyslipidemia is common and undertreated in antiphospholipid syndrome (APS) patients, particularly those with cardiovascular disease history. Achieving cholesterol targets remains a challenge, highlighting the need for improved management strategies in this high-risk group.

Area of Science:

  • Cardiology
  • Rheumatology
  • Metabolic Disorders

Background:

  • Dyslipidemia is a significant risk factor for thrombosis in Antiphospholipid Syndrome (APS).
  • However, lipid profiles and management in APS patients remain understudied.
  • This study addresses the gap by examining lipid profiles and treatment goals in a real-world APS cohort.

Purpose of the Study:

  • To assess the lipid profiles of patients diagnosed with Antiphospholipid Syndrome (APS).
  • To identify risk factors associated with failure to achieve target cholesterol levels in APS patients.
  • To evaluate the current management of dyslipidemia within this specific patient population.

Main Methods:

  • The study included 114 APS outpatients meeting international classification criteria.
  • Lipid levels were determined, and target cholesterol levels were defined using 2019 ESC/EAS guidelines.
  • Data on dyslipidemia history, lipid-lowering therapies, and cardiovascular disease (CVD) history were collected.

Main Results:

  • A high prevalence of unachieved low-density lipoprotein cholesterol (LDL-C) levels was observed in 67.5% of patients.
  • Older age and a history of CVD were independent risk factors for unachieved LDL-C.
  • Triple antiphospholipid antibody (aPL) negativity emerged as a protective factor against unachieved LDL-C.

Conclusions:

  • Dyslipidemia is frequent and inadequately treated in APS patients.
  • Patients with a history of CVD face the greatest risk of future cardiovascular events due to insufficient lipid management.
  • Optimizing dyslipidemia treatment in APS is crucial for reducing cardiovascular risk.
Abstract

Keywords:
Antiphospholipid syndromeatherosclerosiscardiovascular diseasecardiovascular riskdyslipidemialipid-lowering therapies

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