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Striatal dopamine after cortical injury: a reexamination
Experimental Neurology
|July 1, 1987
Summary
Unilateral sensorimotor cortex ablation did not alter dopamine or dihydroxyphenylacetic acid levels in the neostriatum. These findings indicate that striatal dopamine concentrations are not affected by sensorimotor cortex lesions impacting extrapyramidal function.
Area of Science:
- Neuroscience
- Neurochemistry
Background:
- The sensorimotor cortex plays a role in motor control.
- Striatal dopamine and its metabolite dihydroxyphenylacetic acid are crucial for motor function and extrapyramidal pathways.
Purpose of the Study:
- To investigate the impact of unilateral sensorimotor cortex ablation on dopamine and dihydroxyphenylacetic acid concentrations in the neostriatum.
- To determine if sensorimotor cortex lesions influence striatal dopamine levels or turnover.
Main Methods:
- Unilateral sensorimotor cortex ablation was performed in animal models.
- Dopamine and dihydroxyphenylacetic acid concentrations were measured in the left and right neostriatum.
Main Results:
- No significant asymmetry in dopamine or dihydroxyphenylacetic acid was observed in control or sham-operated animals.
- Cortical ablation did not result in changes to dopamine or dihydroxyphenylacetic acid concentrations in the neostriatum.
Conclusions:
- Sensorimotor cortex lesions do not appear to affect striatal dopamine concentrations.
- The influence of sensorimotor cortex lesions on extrapyramidal function does not involve alterations in striatal dopamine levels or turnover.