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Updated: Sep 4, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs

Asmaa S Mekawy1,2, Zina Alaswad1,2, Aya A Ibrahim1,2

  • 1Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, 12578, Giza, Egypt.

Journal, Genetic Engineering & Biotechnology
|July 13, 2022
PubMed

Insights

Severe acute respiratory syndrome coronaviruses (SARS-CoVs) manipulate host DNA damage response (DDR) pathways. Understanding these interactions is crucial for comprehending viral pathogenicity and developing new anti-SARS-CoV-2 drugs.

Area of Science:

  • Virology
  • Molecular Biology
  • Genetics

Background:

  • Viruses, including SARS-CoVs, can induce DNA damage and genome instability in host cells.
  • The interaction between coronaviruses and the host's DNA damage response (DDR) is an understudied but critical area.
  • Understanding these interactions offers insights into viral pathogenicity and host-cell manipulation.

Purpose of the Study:

  • To review known interactions between SARS-CoV and SARS-CoV-2 and host cell DDR pathways.
  • To explore the consequences of coronavirus infection on host genome integrity.
  • To propose new research directions and potential therapeutic strategies against SARS-CoV-2.

Main Methods:

  • Literature review of existing studies on SARS-CoVs and DDR.
  • Analysis of known direct and indirect interactions between viruses and DDR components.
  • Speculative connections to propose potential consequences on DDR mechanisms.

Main Results:

  • Compilation of current knowledge on SARS-CoV and SARS-CoV-2 interactions with host DDR pathways.
  • Identification of gaps in understanding the impact on genome integrity.
  • Hypotheses presented on potential DDR alterations during infection.

Conclusions:

  • Elucidating SARS-CoV-DDR interactions is vital for understanding pathogenicity.
  • Further in vitro and in vivo research is needed to validate proposed mechanisms.
  • This review opens new avenues for developing anti-SARS-CoV-2 therapeutics targeting DDR.
Keywords:
COVID-19DNA damage response (DDR)DNA repairGenomic instabilitySARS-CoVSARS-CoV-2

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