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Re. Re.: "Immunothrombotic dysregulation in Chagas disease and COVID19: a comparative study of anticoagulation"

Laura Pérez-Campos Mayoral1, María Teresa Hernández-Huerta2, Eduardo Pérez-Campos Mayoral1

  • 1Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, 68020, Oaxaca, Mexico.

Molecular and Cellular Biochemistry
|July 13, 2022
PubMed

Insights

This letter addresses commentary on immunothrombotic dysregulation in Chagas disease (CD) and COVID-19. It highlights indirect evidence of thrombotic alterations, including cerebral thrombosis, in CD, even in non-cardiopathic forms.

Area of Science:

  • Hematology and Immunology
  • Infectious Diseases
  • Cardiology

Background:

  • The commentary questions the link between Chagas disease (CD) forms and thromboembolic events.
  • It posits that only thrombogenic alterations in CD with cardiopathy are relevant.
  • This response asserts that indirect evidence supports thrombotic alterations in CD beyond cardiopathy.

Purpose of the Study:

  • To respond to a commentary regarding immunothrombotic dysregulation in Chagas disease (CD) and COVID-19.
  • To clarify the evidence supporting thrombotic alterations in various forms of CD.
  • To reinforce the assertion of thrombotic risks in CD based on existing data.

Main Methods:

  • Review and discussion of previously published data.
  • Comparative analysis of immunothrombotic mechanisms in Chagas disease and COVID-19.
  • Addressing specific points raised in the commentary regarding CD classifications and thrombotic events.

Main Results:

  • Indirect evidence suggests thrombotic alterations, such as cerebral thrombosis, occur in Chagas disease.
  • These alterations may not be limited to CD with cardiopathy.
  • The authors maintain their assertion based on a review of relevant literature.

Conclusions:

  • Thrombotic alterations in Chagas disease warrant further investigation across all disease forms.
  • The discussion highlights the complexity of immunothrombotic dysregulation in infectious diseases.
  • Further research is needed to fully elucidate the relationship between CD, COVID-19, and thrombotic events.

Keywords:
COVID-19Chagas diseaseThrombosis

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