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Updated: Sep 4, 2025

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

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Pharmacogenetic testing in pediatric neurology: a pragmatic study evaluating clinician and patient perceptions

Marie-Anne Pépin1, Anne-Sophie Otis1, Zoë Tremblay1

  • 1Pharmacy Practice Research Unit & Department of Pharmacy, CHU Sainte-Justine, Montréal, Québec, H3T 1C5, Canada.

Personalized Medicine
|July 13, 2022
PubMed

Insights

Clinicians and patients generally view pharmacogenetic testing positively. Integrating these genetic tests into clinical practice is key for advancing personalized medicine and improving patient care.

Area of Science:

  • Pharmacogenetics
  • Clinical Pharmacy
  • Personalized Medicine

Background:

  • Pharmacogenetic testing offers potential for personalized medicine.
  • Understanding perceptions of pharmacogenetic testing is crucial for implementation.

Purpose of the Study:

  • To evaluate perceptions of pharmacogenetic testing among clinicians and patients.
  • To identify barriers and facilitators for integrating pharmacogenetic testing into clinical practice.

Main Methods:

  • Pragmatic mixed-method prospective observational study.
  • Focus groups with hospital pharmacists and neurologists.
  • Surveys with patients and community pharmacists who underwent pharmacogenetic testing.

Main Results:

  • Majority of participants expressed positive views on pharmacogenetic testing.
  • Key themes identified: receptiveness, test characteristics, and integration into practice.
  • Positive perceptions suggest feasibility for clinical adoption.

Conclusions:

  • Favorable perceptions support the future implementation of pharmacogenetics in healthcare.
  • Local integration strategies are essential for leveraging pharmacogenetic testing to enhance patient care.
  • Pharmacogenetic testing is a vital step towards realizing personalized medicine.

Keywords:
cliniciansepilepsypatientspediatricsperceptionspharmacogenetics

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