The Complete Success in Refractory Mooren's Ulcer Treated with Infliximab
Ayşe İdil Çakmak1, Yonca Akova2, Nilgün Yıldırım3
1Department of Ophthalmology, Hatay Mustafa Kemal University Tayfur Ata Sokmen Medical School, Hatay, Turkey.
Purpose:
To describe the management and outcome of two extremely rare and painful cases of Mooren's ulcer, an idiopathic peripheral autoimmune-associated ulcerative corneal disease.
Methods:
Case report with literature review on the management of ocular inflammation in Mooren's ulcer.
Results:
A 47-year-old female and a 76-year-old female presented with progressive bilateral Mooren's ulcer that were refractory to conventional immunosuppressive therapy. Following treatment with infliximab, an anti-tumor necrosis factor alpha, a significant improvement in disease progression was observed, with no corneal thinning or perforation at follow-ups.
Conclusion:
This case report highlights how infliximab can be effective in cases with Mooren's ulcer refractory to conventional therapies.
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