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Updated: Sep 4, 2025

Analyzing Large Protein Complexes by Structural Mass Spectrometry
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Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats

Eva Illes-Toth1, Oliver J Hale1, James W Hughes1

  • 1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Angewandte Chemie (International Ed. in English)
|July 13, 2022
PubMed
Summary

Researchers detected intact protein-drug complexes in rat liver tissue using mass spectrometry. This method identified fatty acid binding protein 1 (FABP1) bound to bezafibrate, enabling in situ drug target characterization.

Keywords:
Ex vivo TissueMass Spectrometry ImagingNative Ambient Mass SpectrometryProtein-Drug Complex

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