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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Etiology and Risk Factors for Admission to the Pediatric Intensive Care Unit in Children With Encephalitis in a

María P Guerrero1, Andrés F Romero2,3, Miguel Luengas4,5

  • 1From the Department of Pediatrics, Universidad del Valle, Cali, Colombia.

The Pediatric Infectious Disease Journal
|July 13, 2022
PubMed

Insights

Pediatric encephalitis patients with generalized seizures, status epilepticus, or low CSF leukocytes require pediatric intensive care unit (PICU) admission. Bacterial and certain viral etiologies significantly increase PICU admission risk.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Encephalitis is a serious neurological condition in children.
  • Identifying risk factors for pediatric intensive care unit (PICU) admission is crucial for timely intervention.

Purpose of the Study:

  • To describe a cohort of pediatric patients diagnosed with encephalitis.
  • To identify risk factors associated with admission to the pediatric intensive care unit (PICU).

Main Methods:

  • A cohort of 202 pediatric patients with encephalitis was analyzed.
  • Data were collected from 14 hospitals in the Colombian Network of Encephalitis in Pediatrics.
  • Multivariate analyses identified factors associated with PICU admission.

Main Results:

  • The primary etiologies included bacterial infections (27%), unspecified viral encephalitis (22%), and enteroviruses (13%).
  • Generalized seizures, status epilepticus, and low cerebrospinal fluid (CSF) leukocyte counts were associated with increased PICU admission.
  • Bacterial etiology, herpes simplex encephalitis, autoimmune encephalitis, and other viral infections significantly elevated the risk of PICU admission compared to enteroviruses.

Conclusions:

  • This study highlights key clinical and etiological factors predicting PICU admission in pediatric encephalitis.
  • Findings from this national collaborative network can aid in early risk stratification for advanced care needs.
Abstract

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