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Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID-19

Andrea Mario Bolla1, Cristian Loretelli2, Laura Montefusco1

  • 1Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.

Diabetes/Metabolism Research and Reviews
|July 13, 2022
PubMed

Insights

Diabetes significantly increases mortality risk in patients with coronavirus disease 19 (COVID-19). This study suggests diabetes and COVID-19 interact via inflammation and vascular dysfunction, worsening patient outcomes.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • Diabetes is linked to increased mortality in COVID-19 patients.
  • COVID-19 involves systemic inflammation and vascular dysfunction, extending beyond pneumonia.
  • Hyperglycemia and diabetes share inflammatory and vascular dysfunction pathways with COVID-19.

Purpose of the Study:

  • To review the connection between diabetes and COVID-19 mortality.
  • To analyze clinical characteristics and outcomes of COVID-19 patients with diabetes.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of clinical, laboratory, and histopathological data from a cohort of nearly 1000 COVID-19 patients.

Main Results:

  • Patients with COVID-19 and diabetes exhibited higher mortality rates.
  • An altered inflammatory profile was observed in diabetic COVID-19 patients.

Conclusions:

  • Diabetes and COVID-19 may synergistically interact through inflammation and vascular dysfunction.
  • This interaction could explain the elevated mortality observed in diabetic individuals with COVID-19.
Abstract

Keywords:
COVID-19diabetesinflammationvascular dysfunction

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