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Related Experiment Videos

Urinary calcium excretion in pregnancy.

R K Marya, S Rathee, M Manrow

    Gynecologic and Obstetric Investigation
    |January 1, 1987
    PubMed
    Summary

    Vitamin D supplementation in pregnancy prevents hypocalcemia and hypocalciuria. Adequate vitamin D ensures normal urinary calcium excretion during pregnancy, highlighting deficiency as the cause of low calcium levels.

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    Area of Science:

    • Obstetrics and Gynecology
    • Nutritional Science
    • Renal Physiology

    Background:

    • Pregnancy is associated with significant physiological changes, including alterations in calcium metabolism.
    • Vitamin D plays a crucial role in calcium homeostasis, which can be affected during gestation.

    Purpose of the Study:

    • To investigate the impact of vitamin D supplementation on urinary calcium excretion and serum calcium levels in pregnant women.
    • To determine if hypocalciuria in pregnancy is a physiological adaptation or indicative of vitamin D deficiency.

    Main Methods:

    • Studied 50 pregnant women at 36 weeks gestation and 50 non-pregnant controls.
    • Assessed urinary calcium excretion and creatinine clearance.
    • Compared a vitamin D-supplemented group (600,000 IU) with a non-supplemented group.

    Main Results:

    • Non-supplemented pregnant women exhibited hypocalcemia and hypocalciuria.
    • Vitamin D-supplemented pregnant women maintained normocalcemia and showed increased urinary calcium excretion compared to controls.
    • Creatinine clearance was elevated in all pregnant women, irrespective of supplementation.

    Conclusions:

    • Increased glomerular filtration rate (GFR) in pregnancy promotes urinary calcium excretion when vitamin D status is adequate.
    • Hypocalciuria during pregnancy strongly suggests vitamin D deficiency, not a normal physiological adaptation.
    • Vitamin D supplementation is crucial for maintaining calcium balance in pregnant individuals.

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