[Enteral viral hepatitis in monkeys]

Area of Science:

• * Virology
• * Zoonotic Diseases
• * Primate Research

Background:

• * Recent discoveries reveal numerous viruses genetically related to human hepatitis A virus (HAV) and hepatitis E virus (HEV) in diverse mammalian species, including bats, rodents, and non-human primates.
• * Zoonotic HEV genotypes have been identified in various animals like wild boars, deer, camels, and rabbits, with related viruses also found in bats, birds, and fish.
• * Monkeys are significant animal models for studying HAV and HEV, offering insights into viral biology, pathogenesis, and aiding in vaccine and drug development.

Purpose of the Study:

• * To review and synthesize published data on HAV and HEV circulation in wild and captive primates.
• * To analyze experimental studies involving HAV and HEV infections in monkeys.
• * To highlight the importance of primate models in understanding and combating hepatitis virus infections.

Main Methods:

• * Comprehensive literature search of scientific databases.
• * Analysis of published research on HAV and HEV in primate populations.
• * Synthesis of findings from experimental infection studies in monkeys.

Main Results:

• * Data indicates circulation of HAV and HEV in various primate species.
• * Experimental studies in monkeys provide valuable information on viral pathogenesis and host response.
• * Primate models are essential for evaluating the efficacy of potential vaccines and therapeutics against HAV and HEV.

Conclusions:

• * Primates are susceptible to HAV and HEV, acting as potential reservoirs or hosts.
• * Understanding viral dynamics in primates is key to preventing zoonotic transmission.
• * Continued research using primate models is vital for advancing HAV and HEV control strategies.