Differential Diagnosis of Preinvasive Lesions in Small Pulmonary Nodules by Dual Source Computed Tomography Imaging

This study was aimed to explore the differential diagnosis value of preinvasive lesions/minimally invasive adenocarcinoma and invasive adenocarcinoma manifesting as small pulmonary nodules under dual source computed tomography (DSCT) imaging. The patients with nodular manifestations of adenocarcinoma in situ (AIS)/microinfiltrating adenocarcinoma (MIA) were selected as group X, including 14 cases. A total of 31 cases with nodular infiltrating adenocarcinoma were selected as group Y. The enhanced dual-energy image obtained by DSCT dual-energy scan was transferred to the software to obtain the energy image and iodine distribution map. SPSS 18.0 was used for statistical analysis. P < 0.05 was considered statistically significant. All measurements were labeled as mean x͞±S standard deviation. In the CT findings of microinfiltrating adenocarcinoma and infiltrating adenocarcinoma, lobulation sign, burr sign, vacuole sign, and pleural depression sign can help the diagnosis of infiltrating adenocarcinoma. The results showed that lobulation sign, burr sign, vacuole sign, and pleural depression sign could be used as the distinguishing feature of preinvasive lesion/microinvasive adenocarcinoma and invasive adenocarcinoma. Receiver-operating characteristic (ROC) curve analysis showed that the critical value, sensitivity, and specificity of lesion diameter ≥1.4 cm and CT value ≥14.14HU for diagnosis of invasive lung adenocarcinoma were 1.32 and 14.14, 88.4% and 94.4%, and 67.3% and 75.8%, respectively. There were substantial differences in CT values between the two groups under low energy level (42-99 kev) (P < 0.05). DSCT dual-energy imaging can quantitatively identify preinvasive pulmonary nodules with multiple parameters.