Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting α-Alkylation of Ketones: Choice of Base01:10

Factors Affecting α-Alkylation of Ketones: Choice of Base

3.3K
α-Alkylation of ketones is achieved in the presence of alkyl halides and a base. The reaction proceeds via the formation of an enolate ion followed by nucleophilic substitution. The choice of base employed is essential as it is the key factor in determining the reaction outcome.
The reaction involving bases like EtO− whose conjugate acid EtOH (pKa = 15.9) is stronger than the ketone (pKa = 19.2) results in an equilibrium mixture with higher ketone concentration. As a consequence,...
3.3K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

101.3K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
101.3K
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

39
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
39

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prolonged fenfluramine use in open-label studies of Dravet or Lennox-Gastaut syndromes: Long-term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness.

Epilepsia·2026
Same author

Consensus statement on the use of standardized early mobilization in pediatric patients admitted to pediatric intensive care units in Italy.

European journal of pediatrics·2026
Same author

Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series.

Developmental medicine and child neurology·2026
Same author

Effects of White Noise on Academic Skills in Children with ADHD and Specific Learning Disorders: New Perspectives for Personalised Rehabilitation and Educational Intervention.

Pediatric reports·2026
Same author

Hemoadsorption in acute pediatric carbamazepine intoxication: a case report and systematic review of extracorporeal therapies.

Pediatric nephrology (Berlin, Germany)·2026
Same author

"Comparison Between Robotic and Conventional Walking Recovery Training Methods in People With Spinal Cord Injury": Systematic Review with Pairwise and Network meta-analysis.

American journal of physical medicine & rehabilitation·2026

Related Experiment Video

Updated: Sep 4, 2025

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
05:42

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

31.6K

KETASER01 protocol: What went right and what went wrong.

Anna Rosati1, Manuela L'Erario2, Roberto Bianchi3

  • 1Neuroscience Department, Meyer Children's Hospital-University of Florence, Florence, Italy.

Epilepsia Open
|July 14, 2022
PubMed
Summary
This summary is machine-generated.

The KETASER01 trial, investigating ketamine for refractory convulsive status epilepticus in children, failed due to poor patient eligibility and recruitment. No conclusions on ketamine

Keywords:
childrennon-profit studyrefractory status epilepticustreatment

More Related Videos

A Protocol for the Production of KLRG1 Tetramer
07:24

A Protocol for the Production of KLRG1 Tetramer

Published on: January 12, 2010

10.1K
qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
07:58

qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes

Published on: March 6, 2019

8.7K

Related Experiment Videos

Last Updated: Sep 4, 2025

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
05:42

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

31.6K
A Protocol for the Production of KLRG1 Tetramer
07:24

A Protocol for the Production of KLRG1 Tetramer

Published on: January 12, 2010

10.1K
qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
07:58

qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes

Published on: March 6, 2019

8.7K

Area of Science:

  • Pediatric Neurology
  • Anesthesiology
  • Clinical Trials

Background:

  • Refractory convulsive status epilepticus (RCSE) in children presents a significant treatment challenge.
  • Conventional anesthetics have limitations in managing RCSE.
  • Novel therapeutic agents are needed for pediatric RCSE.

Purpose of the Study:

  • To assess the efficacy of ketamine compared to conventional anesthetics for treating pediatric RCSE.
  • To evaluate ketamine as a third-line therapy in a multicenter, randomized controlled trial.

Main Methods:

  • The KETASER01 study was a multicenter, randomized, controlled, open-label trial.
  • It aimed to enroll children with RCSE receiving third-line therapy.
  • Ketamine was compared against conventional anesthetics like thiopental.

Main Results:

  • The study was prematurely halted due to low patient eligibility and recruitment.
  • Only 10 patients were enrolled over a 5-year period.
  • Treatment success rates were 40% for both ketamine and thiopental arms, with 60% of patients not achieving seizure control.

Conclusions:

  • The KETASER01 trial could not be completed, thus no conclusions can be drawn regarding ketamine's efficacy for pediatric RCSE.
  • Low patient eligibility and recruitment were the primary reasons for study failure.
  • Future trials require careful consideration of eligibility criteria and recruitment strategies.