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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Total White Blood Cell Count is Associated with Arterial Stiffness Among Hypertensive Patients

Min Huang1, Fajiu Li2, Si Chen3

  • 1Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Angiology
|July 14, 2022
PubMed

Insights

High white blood cell (WBC) counts are linked to increased arterial stiffness and macrovascular damage risk in hypertensive patients. This suggests WBCs may play a role in hypertension-related cardiovascular complications.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Hypertension Research

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • The role of white blood cell (WBC) count in arterial stiffness among hypertensive individuals requires further elucidation.
  • Hypertension is a major risk factor for macrovascular damage.

Purpose of the Study:

  • To investigate the association between total WBC count and arterial stiffness in hypertensive patients.
  • To examine the relationship between WBC count and the risk of macrovascular damage in this population.

Main Methods:

  • Cross-sectional study of 631 hypertensive adults (mean age 65.6 years).
  • Arterial stiffness assessed using brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI).
  • Dose-response relationships evaluated using multivariate regression models.

Main Results:

  • A significant dose-response relationship was observed between higher total WBC count and increased arterial stiffness (elevated baPWV, reduced ABI).
  • Individuals in the highest WBC tertile had significantly worse arterial stiffness markers compared to the lowest tertile.
  • Elevated total WBC count was associated with a greater risk of macrovascular damage (OR 1.86).

Conclusions:

  • Elevated total WBC count is independently associated with arterial stiffness in hypertensive patients.
  • Higher WBC counts may contribute to macrovascular damage in individuals with hypertension.
  • WBC count could serve as a potential biomarker for cardiovascular risk in hypertension management.

Keywords:
ankle-brachial indexarterial stiffnessbrachial-ankle pulse wave velocityhypertensiontotal white blood cell count

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